4-Epidoxycycline
Product Specifications
CAS Number
6543-77-7
Target
EGFR
Related Pathways
Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Bioactivity
4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.
Smiles
O[C@]12[C@]([C@@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H]
Molecular Formula
C22H24N2O8
Molecular Weight
444.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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