QKY-613
Product Specifications
CAS Number
2484713-92-8
Target
Others, cGAS
Related Pathways
Immunology/Inflammation, Others
Bioactivity
QKY-613 is a prodrug designed to enhance immune surveillance by targeting nucleic acid modification pathways. It selectively facilitates the incorporation of 6mdA (N6-methyl-deoxyadenosine) into viral DNA, boosting the DNA's phase separation potential and subsequently increasing cGAS activation levels to strengthen host immune surveillance. In mouse models of viral infection, QKY-613 significantly reduced mortality in aged mice. This compound holds promise for studying immune surveillance mechanisms based on nucleic acid modifications.
Smiles
N(C)C1=C2C(N(C=N2)C3O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OCC5=CC=CC=C5)=O)C)=O)[C@@H](O)C3)=NC=N1
Molecular Formula
C27H31N6O7P
Molecular Weight
582.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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