Antiproliferative agent-64
Product Specifications
CAS Number
1139263-21-0
Target
Microtubule Associated, DNA/RNA Synthesis
Related Pathways
Cytoskeletal Signaling, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
Antiproliferative agent-64 (Compound 76) functions as an inhibitor of the eukaryotic translation initiation factor 4E (eIF4E) and disrupts the secondary structure of mRNA, thereby hindering protein translation. It inhibits the 5' untranslated region (5'UTR) of c-Myc with an EC50 of 1.2 nM and the 5'UTR of tubulin with an EC50 of 40 nM. Additionally, Antiproliferative agent-64 suppresses the proliferation of MDA-MB-231 cells with an EC50 of 7 nM.
Smiles
O[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(OC)C4)C5=CC=C(C#N)C=C5
Molecular Formula
C29H28N2O6
Molecular Weight
500.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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