What is the catalog number for EGFR-IN-137?

The catalog number for EGFR-IN-137 is T203145.

What sizes are available for EGFR-IN-137?

EGFR-IN-137 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does EGFR-IN-137 come in?

EGFR-IN-137 is available in 2 different pack sizes.

Is EGFR-IN-137 in stock?

EGFR-IN-137 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR-IN-137?

EGFR-IN-137 is manufactured by Molfinity.

What is the estimated delivery time for EGFR-IN-137?

Estimated delivery time for EGFR-IN-137 is approximately 10 business day(s), depending on your location.

EGFR-IN-137

Product Specifications

Target

Cytochromes P450, Apoptosis, EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Metabolism, Apoptosis

Bioactivity

EGFR-IN-137 (Compound 4c) acts as an inhibitor of aromatase and EGFR, with IC50 values of 1.67 μg/mL and 0.08 μg/mL, respectively. It hinders the proliferation of cancer cells MCF-7 and MDA-MB-231, with IC50 values of 1.62 μM and 4.14 μM. Additionally, EGFR-IN-137 induces cell cycle arrest at the G0/G1 phase in MDA-MB-231 cells and triggers apoptosis through a caspase-dependent pathway.