EGFR-IN-137
Product Specifications
Target
Cytochromes P450|||Apoptosis|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Metabolism|||Apoptosis
Bioactivity
EGFR-IN-137 (Compound 4c) acts as an inhibitor of aromatase and EGFR, with IC50 values of 1.67 ?g/mL and 0.08 ?g/mL, respectively. It hinders the proliferation of cancer cells MCF-7 and MDA-MB-231, with IC50 values of 1.62 µM and 4.14 µM. Additionally, EGFR-IN-137 induces cell cycle arrest at the G0/G1 phase in MDA-MB-231 cells and triggers apoptosis through a caspase-dependent pathway.
Molecular Formula
C23H21FN6O
Molecular Weight
416.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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