AKV-9
Product Specifications
CAS Number
1307262-15-2
Target
Others
Related Pathways
Others
Bioactivity
AKV-9 is an inhibitor of mutant Cu/Zn superoxide dismutase (SOD1), effectively preventing SOD1-induced protein aggregation and providing protection against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. Additionally, AKV-9 has been shown to improve amyotrophic lateral sclerosis (ALS) in mouse models and extend their lifespan.
Smiles
C(F)(F)(F)C1=CC(C(F)(F)F)=CC(O[C@@H](C)C2CC(=O)CC(=O)C2)=C1
Molecular Formula
C16H14F6O3
Molecular Weight
368.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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