O-Desmethylcarvedilol
Product Specifications
CAS Number
72956-44-6
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism
Bioactivity
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 μM) . Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 μg/kg) .
Smiles
OC=1C=CC=CC1OCCNCC(O)COC2=CC=CC=3NC=4C=CC=CC4C23
Molecular Formula
C23H24N2O4
Molecular Weight
392.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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