IRAK1/4/pan-FLT3 Kinase-IN-1
Product Specifications
CAS Number
2760328-82-1
Target
FLT, IRAK
Related Pathways
Immunology/Inflammation, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis
Bioactivity
IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, demonstrating IC50 values of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. It exhibits favorable pharmacokinetic properties and holds promise for research in acute myeloid leukemia, with survival extension effects comparable to Gilteritinib.
Smiles
C(C)(C)(O)C1=CN2C(=CN=C2C=C1OC)C=3N=C(N[C@@H]4[C@@H](F)CCNC4)C=CC3
Molecular Formula
C21H26FN5O2
Molecular Weight
399.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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