IRF1-IN-2
Product Specifications
CAS Number
708245-32-3
Target
Pyroptosis|||Caspase|||PARP|||Interleukin|||Glutathione Peroxidase|||IFNAR
Related Pathways
Chromatin/Epigenetic|||Metabolism|||Apoptosis|||DNA Damage/DNA Repair|||Proteases/Proteasome|||Immunology/Inflammation
Purity
0.9985
Bioactivity
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC
Molecular Formula
C18H20N2O4S
Molecular Weight
360.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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