MN-25
Product Specifications
CAS Number
501926-82-5
Target
Cannabinoid Receptor, TNF
Related Pathways
Apoptosis, GPCR/G Protein
Bioactivity
MN-25 (compound 4a) is an orally active indole pyridinone that functions as a novel cannabinoid ligand. It exhibits binding affinities (Ki) of 245 nM for CB1 and 11 nM for CB2 receptors. As a CB2 agonist, MN-25 inhibits TNF-R release from human peripheral blood mononuclear cells in vitro, with an IC50 of 33 μM. However, in an acute inflammation model in mice, MN-25 did not demonstrate efficacy at oral doses up to 50 mg/kg.
Smiles
C(CN1CCOCC1)N2C=3C(C(C(N[C@H]4[C@]5(C)C[C@](C4(C)C)(CC5)[H])=O)=C2)=CC=CC3OC
Molecular Formula
C26H37N3O3
Molecular Weight
439.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
040080-ML405 100 µL
PIPPIN, ID (CSDC2, PIPPIN, Cold shock domain-containing protein C2, RNA-binding protein PIPPin) (MaxLight 405) discontinued
Sign In for Pricing
View Details MBS6226520-01 0.1 mL
ANGPTL7 (Angiopoietin-like 7, AngX, CDT6, RP4-647M16.2, dJ647M16.1) (MaxLight 650)
Sign In for Pricing
View Details 
MBS6226520-02 5x 0.1 mL
ANGPTL7 (Angiopoietin-like 7, AngX, CDT6, RP4-647M16.2, dJ647M16.1) (MaxLight 650)
Sign In for Pricing
View Details