MN-25
Product Specifications
CAS Number
501926-82-5
Target
Cannabinoid Receptor|||TNF
Related Pathways
Apoptosis|||GPCR/G Protein
Bioactivity
MN-25 (compound 4a) is an orally active indole pyridinone that functions as a novel cannabinoid ligand. It exhibits binding affinities (Ki) of 245 nM for CB1 and 11 nM for CB2 receptors. As a CB2 agonist, MN-25 inhibits TNF-R release from human peripheral blood mononuclear cells in vitro, with an IC50 of 33 ?M. However, in an acute inflammation model in mice, MN-25 did not demonstrate efficacy at oral doses up to 50 mg/kg.
Smiles
C(CN1CCOCC1)N2C=3C(C(C(N[C@H]4[C@]5(C)C[C@](C4(C)C)(CC5)[H])=O)=C2)=CC=CC3OC
Molecular Formula
C26H37N3O3
Molecular Weight
439.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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