TLR4/NF-κB-IN-1
Product Specifications
CAS Number
3050836-94-4
Target
NF-κB, IκB/IKK, TLR
Related Pathways
NF-κB, Immunology/Inflammation
Bioactivity
TLR4/NF-κB-IN-1 (Compound 7x) is an orally bioavailable inhibitor targeting the TLR4/NF-κB signaling pathway, with anti-inflammatory properties and the ability to cross the blood-brain barrier. It can alleviate LPS-induced acute neuroinflammation in mice and downregulate the protein expression of TLR4, P-NF-κB, and P-IκB-α.
Smiles
O=C1NC2=CC=C(C=C2N1)NC3=NC=NC4=C3C=CN4CC5=CC=C(F)C=C5
Molecular Formula
C20H15FN6O
Molecular Weight
374.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BULC-204 Each
Desktop Multi frequency type Ultrasonic Cleaner BULC-204
Sign In for Pricing
View Details 
BNC472560-100 1x 100 µL
Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) (rIM373), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940627-100 1x 100 µL
Cytokeratin 8 (TS1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details