TLR4/NF-κB-IN-1
Product Specifications
CAS Number
3050836-94-4
Target
NF-κB, IκB/IKK, TLR
Related Pathways
NF-κB, Immunology/Inflammation
Bioactivity
TLR4/NF-κB-IN-1 (Compound 7x) is an orally bioavailable inhibitor targeting the TLR4/NF-κB signaling pathway, with anti-inflammatory properties and the ability to cross the blood-brain barrier. It can alleviate LPS-induced acute neuroinflammation in mice and downregulate the protein expression of TLR4, P-NF-κB, and P-IκB-α.
Smiles
O=C1NC2=CC=C(C=C2N1)NC3=NC=NC4=C3C=CN4CC5=CC=C(F)C=C5
Molecular Formula
C20H15FN6O
Molecular Weight
374.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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