LW1564
Product Specifications
CAS Number
2668337-39-9
Target
AMPK, HIF/HIF Prolyl-Hydroxylase
Related Pathways
PI3K/Akt/mTOR signaling, Metabolism, Chromatin/Epigenetic
Bioactivity
LW1564 is an HIF-1α inhibitor with an IC50 of 1.2 μM in HepG2 cells. It suppresses mitochondrial respiration, reduces ATP production, and stimulates HIF-1α degradation, thereby inhibiting the proliferation of various cancer cells with a GI50 ranging from 0.4 to 4.6 μM. Additionally, LW1564 activates the AMPK signaling pathway and inhibits lipid synthesis. In HepG2 xenograft mouse models, LW1564 demonstrates antitumor activity.
Smiles
O=C(N1CCN(CC2=CC=C(C=C2)C(F)(F)F)CC1)COC3=CC=C(C=C3)C45CC6CC(CC(C(=O)N7CC8=CC(OC)=C(OC)C=C8CC7)(C6)C4)C5
Molecular Formula
C42H48F3N3O5
Molecular Weight
731.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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