MU1210
Product Specifications
CAS Number
2275601-87-9
Target
DYRK, CDK
Related Pathways
Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint
Bioactivity
MU1210 (compound 12f) acts as an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 with IC50 values of 8, 20, and 12 nM, respectively, and exhibits IC50 values of 187 and 1309 nM for HIPK1 and DYRK2. Additionally, MU1210 demonstrates favorable pharmacokinetic properties in mice (10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed) .
Smiles
N=1C=CC(=CC1)C=2C=CC=C(C2)C3=COC=4C=CC(=NC43)C=5C=NN(C5)C
Molecular Formula
C22H16N4O
Molecular Weight
352.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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