Emavusertib Phosphate
Product Specifications
CAS Number
2376399-38-9
Target
MyD88, Apoptosis, FLT, IRAK, NF-κB
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis, Immunology/Inflammation
Bioactivity
Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.
Smiles
P(=O)(O)(O)O.N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6
Molecular Formula
C24H28N7O9P
Molecular Weight
589.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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