Ro 44-3888
Product Specifications
CAS Number
144412-18-0
Bioactivity
Ro 44-3888, the active component of sibrafiban, achieves predictable plasma concentrations when administered orally in its prodrug form, Ro 48-3657. Upon reaching a steady state after the second dose, Ro 44-3888 exhibits concentration-dependent inhibition of platelet aggregation and prolongs bleeding time. These findings suggest that Ro 44-3888 merits further evaluation, especially in patients at high risk of arterial thrombosis and those with acute coronary syndrome, due to its reliable absorption.
Smiles
C(N[C@H](C(=O)N1CCC(OCC(O)=O)CC1)C)(=O)C2=CC=C(C(=N)N)C=C2
Molecular Formula
C18H24N4O5
Molecular Weight
376.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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