Emavusertib Mesylate
Product Specifications
CAS Number
2376399-40-3
Target
MyD88|||NF-?B|||IRAK|||FLT|||Apoptosis
Related Pathways
Apoptosis|||Immunology/Inflammation|||NF-?B|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
Emavusertib Mesylate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, demonstrating antitumor activity. In cell lines of ABC DLBCL and AML, CA-4948 shows significant cellular activity. Moreover, it exhibits moderate to high selectivity in screening assays of 329 kinases and has impressive pharmacokinetic and pharmacodynamic profiles (ADME and PK), with good oral bioavailability in mice, rats, and dogs. In pertinent tumor models, CA-4948 achieves over 90% tumor growth inhibition and shows excellent correlation with in vivo PD modulation.
Smiles
S(C)(=O)(=O)O.N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6
Molecular Formula
C25H29N7O8S
Molecular Weight
587.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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