PaPE-1
Product Specifications
CAS Number
2107327-36-4
Bioactivity
PaPE-1 is a pathway-preferential estrogen that activates extracellular nuclear signaling pathways without affecting nuclear signaling pathways. It exerts anti-apoptotic effects by inhibiting A?-induced caspase activity and reducing chromatin condensation associated with apoptosis, thereby preventing neuronal cell death. Additionally, post-treatment with PaPE-1 decreases the mRNA expression of apoptosis-specific factors (such as Bax, Gsk3b, Fas, and Fasl) under A? influence, while upregulating Bcl2 expression.
Smiles
O[C@@H]1C=2C(=CC(=CC2)C3=CC(C)=C(O)C(C)=C3)CC1
Molecular Formula
C17H18O2
Molecular Weight
254.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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