PF-03654764 tosylate
Product Specifications
CAS Number
1337536-85-2
Bioactivity
PF-03654764 exhibits high affinity for the human H3 receptor, but displays significantly lower affinity for the rat H3 receptor, with over 1000-fold selectivity against other human histamine receptor subtypes (H1, H2, and H4) . In functional assays measuring cAMP using reporter gene assays (β-lactamase) conducted in HEK293 cells stably expressing the full-length human or rat H3 receptor, PF-03654764 demonstrated potent antagonist properties.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.F[C@@]1(C[C@@H](C(NCC(C)C)=O)C1)C2=CC(F)=C(CN3CCCC3)C=C2
Molecular Formula
C20H28F2N2O xC7H8O3S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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