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CEP-751

Product Specifications

CAS Number

156177-59-2

Bioactivity

CEP-751 (also known as KT-6587) is a potent Trk inhibitor. It exhibits significant growth inhibition in MBL cell line D283 (Day 39, P=0.031) and demonstrates moderate growth inhibition in IMR5 (P=0.062) and CHP-134 (P=0.049) cell lines. Additionally, CEP-751 induces apoptosis in CHP-134 tumors. It may be a useful compound for treating NBL or MBL. At a concentration of 100 nM, CEP-751 inhibits the receptor tyrosine kinase activity of neurotrophin receptors trkA, trkB, and trkC. It also shows antitumor effects on tumors derived from trkA-transfected NIH3T3 cells.

Smiles

C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(CO)OC)[H])=CC=CC8

Molecular Formula

C27H23N3O4

Molecular Weight

453.49

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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