AZD5991 sodium
Product Specifications
CAS Number
2143061-85-0
Bioactivity
AZD5991 is a potent and selective Mcl-1 inhibitor aimed at treating hematological cancers. As a well-designed macrocyclic compound, AZD5991 exhibits sub-nanomolar affinity for Mcl-1. It primarily inhibits the myeloid cell leukemia-1 protein (Mcl-1; Bcl2-L-3), showing potential pro-apoptotic and anti-tumor activity. AZD5991 binds to Mcl-1, preventing its interaction with certain pro-apoptotic proteins, leading to apoptosis in cells overexpressing Mcl-1.
Smiles
O=C(C1=C2C3=C(N1C)C(C4=C(C)N(C)N=C4CSCC5=NN(C)C(CSC6=CC7=C(C=CC=C7)C(OCCC2)=C6)=C5)=C(Cl)C=C3)[O-].[Na+]
Molecular Formula
C35H33ClN5NaO3S2
Molecular Weight
694.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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