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AZD5991 sodium

Product Specifications

CAS Number

2143061-85-0

Bioactivity

AZD5991 is a potent and selective Mcl-1 inhibitor aimed at treating hematological cancers. As a well-designed macrocyclic compound, AZD5991 exhibits sub-nanomolar affinity for Mcl-1. It primarily inhibits the myeloid cell leukemia-1 protein (Mcl-1; Bcl2-L-3), showing potential pro-apoptotic and anti-tumor activity. AZD5991 binds to Mcl-1, preventing its interaction with certain pro-apoptotic proteins, leading to apoptosis in cells overexpressing Mcl-1.

Smiles

O=C(C1=C2C3=C(N1C)C(C4=C(C)N(C)N=C4CSCC5=NN(C)C(CSC6=CC7=C(C=CC=C7)C(OCCC2)=C6)=C5)=C(Cl)C=C3)[O-].[Na+]

Molecular Formula

C35H33ClN5NaO3S2

Molecular Weight

694.24

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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