AZASPIRENE
Product Specifications
CAS Number
461644-34-8
Target
VEGFR, Raf
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Angiogenesis
Bioactivity
Azaspirene, a novel angiogenesis inhibitor, is based on the 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione framework. Previous studies have shown that Azaspirene effectively inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVEC), demonstrating a potentially effective dosage. Moreover, azaspirene analogs may exhibit potential antitumor effects against uterine adenocarcinoma, possibly through significant anti-angiogenic activity.
Smiles
O[C@@H]1[C@@]2(OC(/C=C/C=C/CC)=C(C)C2=O)C(=O)N[C@]1(CC3=CC=CC=C3)O
Molecular Formula
C21H23NO5
Molecular Weight
369.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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