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GDC-0134

Product Specifications

CAS Number

1637394-01-4

Target

JNK

Related Pathways

MAPK

Bioactivity

GDC-0134, a dual leucine zipper kinase (DLK) inhibitor, exhibits brain penetration properties. It inhibits DLK to prevent neuronal degeneration and block JNK activation, potentially treating amyotrophic lateral sclerosis (ALS) . It has been assessed in a phase 1 study aimed at treating ALS patients.

Smiles

FC1(F)CN(C=2N=C(C=C(N2)C=3C=C(OC(F)F)C(N)=NC3)N4[C@]5(C[C@@](C4)(OC5)[H])[H])CC1

Molecular Formula

C19H20F4N6O2

Molecular Weight

440.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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