GDC-0134
Product Specifications
CAS Number
1637394-01-4
Target
JNK
Related Pathways
MAPK
Bioactivity
GDC-0134, a dual leucine zipper kinase (DLK) inhibitor, exhibits brain penetration properties. It inhibits DLK to prevent neuronal degeneration and block JNK activation, potentially treating amyotrophic lateral sclerosis (ALS) . It has been assessed in a phase 1 study aimed at treating ALS patients.
Smiles
FC1(F)CN(C=2N=C(C=C(N2)C=3C=C(OC(F)F)C(N)=NC3)N4[C@]5(C[C@@](C4)(OC5)[H])[H])CC1
Molecular Formula
C19H20F4N6O2
Molecular Weight
440.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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