(Rac) -Salvianic acid A (sodium)

(Rac) -Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913) . Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism) . Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[67920-52-9]

Product Name Alternative

(Rac) -Danshensu (sodium) ; (Rac) -Tanshinol (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Keap1-Nrf2; Mitochondrial Metabolism; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rac-salvianic-acid-a-sodium.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=CC(CC(C(O[Na])=O)O)=C1

Molecular Formula

C9H9NaO5

Molecular Weight

220.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43 (4) :771-780. |[2]V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne) . 2020 Sep 30:11:568436. |[3]Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. |[4]Wu Y, et al. The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms. Oxid Med Cell Longev. 2020 Sep 25;2020:5472096. doi: 10.1155/2020/5472096.|[5]Zhao QT, et al. Salvianic acid A inhibits lipopolysaccharide-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells. Chin J Nat Med. 2012 Jan;10 (1) :53-7.|[6]Zhao QT, et al. Salvianic acid A inhibits lipopolysaccharide-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells. Chin J Nat Med. 2012 Jan;10 (1) :53-7.|[7]Jia D, et al. Salvianic acid A sodium protects HUVEC cells against tert-butyl hydroperoxide induced oxidative injury via mitochondria-dependent pathway. Chem Biol Interact. 2018 Jan 5;279:234-242.