PfCLK3-IN-1
Product Specifications
Target
ABC Transporter|||Endogenous Metabolite|||Parasite
Related Pathways
Microbiology/Virology|||Membrane transporter/Ion channel|||Metabolism
Bioactivity
PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.
Smiles
OC(C(C=C1)=CC=C1C2=C(C=C(C3=CC(CN4CCN(C(CCl)=O)CC4)=CC=C3OC)N5)C5=NC=C2)=O
Molecular Formula
C28H27ClN4O4
Molecular Weight
518.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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