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Tandutinib sulfate

Product Specifications

CAS Number

387867-14-3

Target

Topoisomerase|||Drug-Linker Conjugates for ADC|||Apoptosis|||Microtubule Associated|||PDGFR|||c-Kit

Related Pathways

Apoptosis|||Antibody-drug Conjugate/ADC Related|||Angiogenesis|||DNA Damage/DNA Repair|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

Bioactivity

Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 ?M. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 ?M and 0.20 ?M respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.

Smiles

O=C(NC1=CC=C(OC(C)C)C=C1)N2CCN(C=3N=CN=C4C=C(OCCCN5CCCCC5)C(OC)=CC43)CC2.O=S(=O)(O)O

Molecular Formula

C31H44N6O8S

Molecular Weight

660.78

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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