PROTAC BRM/BRG1 degrader-3
Product Specifications
CAS Number
2933125-05-2
Target
Epigenetic Reader Domain, Endogenous Metabolite
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
PROTAC BRM/BRG1 degrader-3 (compound 304) is a PROTAC-based degrader of BRM/BRG1. In SW1573 cells, it degrades BRM with a DC50 of less than 1 nM and BRG1 with a DC50 greater than 1 nM. PROTAC BRM/BRG1 degrader-3 exhibits antitumor activity and inhibits the proliferation of A549 cells with an IC50 of 0.6 nM.
Smiles
N(C(C)C)C=1C=2C(N(N1)C3CCN(CC4CCN(CC4)C=5C=C(C(C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)C)ON5)CC3)=CC(=NN2)C9=C(O)C=CC=C9
Molecular Formula
C50H63N11O5S
Molecular Weight
930.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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