Flucopride
Product Specifications
CAS Number
1639925-34-0
Target
Cholinesterase (ChE) |||5-HT Receptor
Related Pathways
GPCR/G Protein|||Neuroscience
Bioactivity
Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h) 5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h) 5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.
Smiles
O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC2)CC3CCCCC3
Molecular Formula
C22H33FN2O2
Molecular Weight
376.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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