NS-062
Product Specifications
CAS Number
2226257-92-5
Target
Antibacterial|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Microbiology/Virology
Bioactivity
NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 ?M. It also exhibits antitumor activity in a murine H1975 xenograft model.
Smiles
N(C=1C2=C(C=C(OCCCN3CCOCC3)C(NC(=O)[C@@H]4N(C(C(Cl)F)=O)CCC4)=C2)N=CN1)C5=CC(Cl)=C(F)C=C5
Molecular Formula
C28H30Cl2F2N6O4
Molecular Weight
623.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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