NS-062
Product Specifications
CAS Number
2226257-92-5
Target
Antibacterial|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Microbiology/Virology
Bioactivity
NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 ?M. It also exhibits antitumor activity in a murine H1975 xenograft model.
Smiles
N(C=1C2=C(C=C(OCCCN3CCOCC3)C(NC(=O)[C@@H]4N(C(C(Cl)F)=O)CCC4)=C2)N=CN1)C5=CC(Cl)=C(F)C=C5
Molecular Formula
C28H30Cl2F2N6O4
Molecular Weight
623.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6202936-01 0.1 mL
RFWD3 (RING Finger and WD Repeat Domain-containing Protein 3, E3 Ubiquitin-protein Ligase RFWD3, RING Finger Protein 201, RNF201) (MaxLight 490)
Ask
View Details 
MBS6202936-02 5x 0.1 mL
RFWD3 (RING Finger and WD Repeat Domain-containing Protein 3, E3 Ubiquitin-protein Ligase RFWD3, RING Finger Protein 201, RNF201) (MaxLight 490)
Ask
View Details 