Dracorhodin perchlorate

Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product that can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[125536-25-6]

Product Name Alternative

Dracohodin perochlorate

UNSPSC

12352005

Target

Akt; Apoptosis; Caspase; MDM-2/p53; NF-κB; PARP; PI3K; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dracorhodin-perchlorate.html

Purity

99.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(OC)C2=CC=C(C3=CC=CC=C3)[O+]=C2C=C1O.O=Cl(=O)([O-])=O

Molecular Formula

C17H15ClO7

Molecular Weight

366.75

References & Citations

[1]Chen X, et al. Dracorhodin perchlorate induces the apoptosis of glioma cells. Oncol Rep. 2016 Apr;35 (4) :2364-72.|[2]Xia M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci. 2004 Jun;95 (2) :273-83.|[3]Rasul A, et al. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct;17 (10) :1104-19. |[4]Jiang X, et al. Dracorhodin perchlorate regulates fibroblast proliferation to promote rat's wound healing. J Pharmacol Sci. 2018 Feb;136 (2) :66-72.|[5]He Y, et al. Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31 (2) :215.|[6]Yu JH, et al. Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci. 2013 Jul 7;10 (9) :1149-56.|[7]Xiong Z, et al. Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats. Evid Based Complement Alternat Med. 2022 Apr 14;2022:9050686.|[8]Liu L, et al. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. FEBS J. 2019 Sep;286 (18) :3718-3736.