Anti-MRSA agent 20

Anti-MRSA agent 20 (Compound a4) is an antimicrobial agent targeting MRSA with a minimum inhibitory concentration (MIC) of less than 0.03125 μg/mL. It binds to the peptidyl transferase center of the ribosome, inhibiting the synthesis of MRSA toxins and bacterial division, thereby suppressing bacterial survival. Furthermore, Anti-MRSA agent 20 significantly reduces the pulmonary MRSA load and diminishes lung damage in mice infected with MRSA (ED50= 6.48 mg/kg) .