(+) -ITD-1
Product Specifications
CAS Number
1409968-46-2
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Bioactivity
(+) -ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs) .
Smiles
C(OCC)(=O)C=1[C@@H](C2=C(NC1C)CC(C)(C)CC2=O)C3=CC=C(C=C3)C4=CC=CC=C4
Molecular Formula
C27H29NO3
Molecular Weight
415.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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