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(+) -ITD-1

Product Specifications

CAS Number

1409968-46-2

Target

TGF-beta/Smad

Related Pathways

Stem Cells

Bioactivity

(+) -ITD-1 is an inhibitor of TGF-?, effectively inhibiting TGF-?2 with an IC50 of 0.46 ?M. It promotes the degradation of the TGF-? type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs) .

Smiles

C(OCC)(=O)C=1[C@@H](C2=C(NC1C)CC(C)(C)CC2=O)C3=CC=C(C=C3)C4=CC=CC=C4

Molecular Formula

C27H29NO3

Molecular Weight

415.52

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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