BET-IN-27
Product Specifications
CAS Number
3054869-29-0
Target
Epigenetic Reader Domain, TGF-beta/Smad
Related Pathways
Stem Cells, Chromatin/Epigenetic
Bioactivity
BET-IN-27 (compound 6C) is an orally active BET inhibitor with IC50 values of 3.3 nM (BRD4-BD2), 3.4 nM (BRD4-BD1), 4.1 nM (BRD2-BD1), 20.4 nM (BRD3-BD1), and 42.0 nM (BRDT-BD1) . It also exhibits antiproliferative activity.
Smiles
O=C1C=2NC=CC2C(=CN1C)C3=NC=4C=C(SC4C(=N3)N5CCOCC5)C(O)(C)C
Molecular Formula
C21H23N5O3S
Molecular Weight
425.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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