EGFR-IN-132
Product Specifications
CAS Number
2809982-20-3
Target
EGFR, Neurotensin Receptor
Related Pathways
Angiogenesis, GPCR/G Protein, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.
Smiles
C[C@H]1CN2C=3C(NC2=NC(=O)C=4C=C(C5=C(OCCC1)N(C)N=C5)N=C(C)C4)=CC(NC6COC6)=CC3
Molecular Formula
C27H31N7O3
Molecular Weight
501.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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