Androgen receptor antagonist 12
Product Specifications
CAS Number
6605-17-0
Target
Androgen Receptor, OAT, OCT
Related Pathways
Endocrinology/Hormones, Membrane transporter/Ion channel
Bioactivity
Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 μM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.
Smiles
O=[N+](C1=CN=C(NC2=CC=CC(C(F)(F)F)=C2)C=C1)[O-]
Molecular Formula
C12H8F3N3O2
Molecular Weight
283.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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