TGase2-IN-1
Product Specifications
CAS Number
2244702-64-3
Target
Glutaminase, Ligands for Target Protein for PROTAC
Related Pathways
Proteases/Proteasome, PROTAC
Bioactivity
TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 μM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 μM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.
Smiles
O=C1C=C(N)C(=O)C2=NC(=CC=C12)C=3C=CC(OC4CCN(CC4)C(C)C)=CC3
Molecular Formula
C23H25N3O3
Molecular Weight
391.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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