EGFR-IN-134
Product Specifications
Target
Bcl-2 Family, Caspase, Apoptosis, Necroptosis, EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Apoptosis, Proteases/Proteasome, Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 μM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.
Smiles
O=C(C1=NN(C2=CC=C([N+]([O-])=O)C=C2)C3N1CCC4=C3C=C(OC)C(OC)=C4)/C=C/C5=CN(C6=CC=CC=C6)N=C5C7=CC=CC=C7
Molecular Formula
C36H30N6O5
Molecular Weight
626.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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