What is the catalog number for EGFR-IN-134?

The catalog number for EGFR-IN-134 is T201573.

What sizes are available for EGFR-IN-134?

EGFR-IN-134 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does EGFR-IN-134 come in?

EGFR-IN-134 is available in 2 different pack sizes.

Is EGFR-IN-134 in stock?

EGFR-IN-134 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR-IN-134?

EGFR-IN-134 is manufactured by Molfinity.

What is the estimated delivery time for EGFR-IN-134?

Estimated delivery time for EGFR-IN-134 is approximately 10 business day(s), depending on your location.

EGFR-IN-134

Product Specifications

Target

Bcl-2 Family, Caspase, Apoptosis, Necroptosis, EGFR

Related Pathways

JAK/STAT signaling, Angiogenesis, Apoptosis, Proteases/Proteasome, Tyrosine Kinase/Adaptors

Bioactivity

EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 μM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.