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EGFR/VEGFR2-IN-3

Product Specifications

CAS Number

710972-61-5

Target

Apoptosis, VEGFR, EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, Angiogenesis

Bioactivity

EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 μM for EGFR, 0.142 μM for VEGFR-2, and 3.428 μM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.

Smiles

O=C(NNC(=S)NC1=CC=C(C=C1)C)CSC2=NC=3C=CC=CC3C(=O)N2C4=CC=C(Cl)C=C4

Molecular Formula

C24H20ClN5O2S2

Molecular Weight

510.03

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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