EGFR/VEGFR2-IN-3
Product Specifications
CAS Number
710972-61-5
Target
Apoptosis|||VEGFR|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Apoptosis|||Angiogenesis
Bioactivity
EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.
Smiles
O=C(NNC(=S)NC1=CC=C(C=C1)C)CSC2=NC=3C=CC=CC3C(=O)N2C4=CC=C(Cl)C=C4
Molecular Formula
C24H20ClN5O2S2
Molecular Weight
510.03
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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