TRAP-1
Product Specifications
Target
Apoptosis|||Autophagy
Related Pathways
Apoptosis|||Autophagy
Bioactivity
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 ?M and 0.531 ?M in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.
Molecular Formula
C57H66ClF3N11O3PS
Molecular Weight
1108.69
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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