CL-13
Product Specifications
Target
Beta Amyloid, Cholinesterase (ChE)
Related Pathways
Neuroscience
Bioactivity
CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.
Smiles
CC(C)(C)C1=CC(/C=N/NC(NC2=C3C(C=CC=C3)=NC4=C2C=CC=C4)=S)=CC(C(C)(C)C)=C1O
Molecular Formula
C29H32N4OS
Molecular Weight
484.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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