ATM Inhibitor-11
Product Specifications
CAS Number
2878473-51-7
Target
ATM/ATR
Related Pathways
PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Bioactivity
ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.
Smiles
O=C1N(C=2C=NC=3C=C(F)C(=CC3C2N1C(C)C)C=4C=NC(OCCCN5CCN(C)CC5)=CC4)C
Molecular Formula
C27H33FN6O2
Molecular Weight
492.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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