DD205-291
Product Specifications
CAS Number
3047066-15-6
Target
PROTACs|||GluR
Related Pathways
PROTAC|||Neuroscience
Bioactivity
DD205-291 is an orally active PROTAC HPK1 degrader with a DC50 of 5.3 nM. It inhibits SLP-76 phosphorylation and induces IL-2 and IFN-?.
Smiles
O=C1NC(=O)CCN1C2=CC(=CC=C2Cl)C(=O)N3CCC(CC3)CC4CCN(C5=NC=C(C=C5)C6=NC7=C(N=C6)NC=C7C=8C=NN(C8)CC(F)(F)F)CC4
Molecular Formula
C38H38ClF3N10O3
Molecular Weight
775.22
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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