TMX-3013
Product Specifications
CAS Number
2488761-18-6
Target
JNK|||CDK
Related Pathways
Cell Cycle/Checkpoint|||MAPK
Bioactivity
TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.
Smiles
O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)S(=O)(=O)N
Molecular Formula
C17H14BrFN6O3S
Molecular Weight
481.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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